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Systematic name YBR135W
Gene name CKS1
Feature type ORF, Verified
Coordinates Chr II:504854..505306
Primary SGDID S000000339

Description of YBR135W: Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters[1][2][3][4]


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  1. Hadwiger JA, et al. (1989) The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex. Mol Cell Biol 9(5):2034-41 SGD PMID 2664468
  2. Kaiser P, et al. (1999) Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev 13(9):1190-202 SGD PMID 10323869
  3. Morris MC, et al. (2003) Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423(6943):1009-13 SGD PMID 12827207
  4. Reynard GJ, et al. (2000) Cks1 is required for G(1) cyclin-cyclin-dependent kinase activity in budding yeast. Mol Cell Biol 20(16):5858-64 SGD PMID 10913169

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