Difference between revisions of "YHR005C"
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| − | '''Description of YHR005C:''' GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome<ref name='S000117071'>Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 {{SGDpaper|S000117071}} PMID 16839886</ref><ref name='S000074143'>Guo M, et al. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24 {{SGDpaper|S000074143}} PMID 14536090</ref><ref name='S000060798'>Dohlman HG and Thorner JW (2001) Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem 70 | + | '''Description of YHR005C:''' GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome<ref name='S000117071'>Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 {{SGDpaper|S000117071}} PMID 16839886</ref><ref name='S000074143'>Guo M, et al. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24 {{SGDpaper|S000074143}} PMID 14536090</ref><ref name='S000060798'>Dohlman HG and Thorner JW (2001) Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem 70:703-54 |
{{SGDpaper|S000060798}} PMID 11395421</ref> | {{SGDpaper|S000060798}} PMID 11395421</ref> | ||
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Revision as of 13:05, 18 July 2007
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| Systematic name | YHR005C |
| Gene name | GPA1 |
| Aliases | CDC70, DAC1, SCG1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:114912..113494 |
| Primary SGDID | S000001047 |
Description of YHR005C: GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome[1][2][3]
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References
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- ↑ Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 SGD PMID 16839886
- ↑ Guo M, et al. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24 SGD PMID 14536090
- ↑ Dohlman HG and Thorner JW (2001) Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem 70:703-54 SGD PMID 11395421
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