YHR005C

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Systematic name YHR005C
Gene name GPA1
Aliases CDC70, DAC1, SCG1
Feature type ORF, Verified
Coordinates Chr VIII:114917..113499
Primary SGDID S000001047


Description of YHR005C: GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome[1][2][3]




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References

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  1. Dohlman HG and Thorner JW (2001) Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem 70():703-54 SGD PMID 11395421
  2. Guo M, et al. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24 SGD PMID 14536090
  3. Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 SGD PMID 16839886

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