Difference between revisions of "YOR254C"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005780 YOR254C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SEC63 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SEC63 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XV:807024..805033 | |nowrap| Chr XV:807024..805033 | ||
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+ | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005780 | ||
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− | '''Description of | + | '''Description of YOR254C:''' Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER<ref name='S000074616'>Misselwitz B, et al. (1999) Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem 274(29):20110-5 {{SGDpaper|S000074616}} PMID 10400622</ref><ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 |
{{SGDpaper|S000060140}} PMID 11226176</ref> | {{SGDpaper|S000060140}} PMID 11226176</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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<protect> | <protect> |
Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
Systematic name | YOR254C |
Gene name | SEC63 |
Aliases | PTL1 |
Feature type | ORF, Verified |
Coordinates | Chr XV:807024..805033 |
Primary SGDID | S000005780 |
Description of YOR254C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with SEC62
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]
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References
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- ↑ Misselwitz B, et al. (1999) Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem 274(29):20110-5 SGD PMID 10400622
- ↑ 2.0 2.1 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ submitted by Colin Stirling on 2003-02-05
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