Difference between revisions of "YKL089W"

From SGD-Wiki
Jump to: navigation, search
(Automated import of articles)
 
(Automated import of articles)
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
 
<!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN-->
 
<!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN-->
 
{{PageTop}}
 
{{PageTop}}
 +
<protect>
 
{|{{Prettytable}} align = 'right' width = '200px'
 
{|{{Prettytable}} align = 'right' width = '200px'
 
|-
 
|-
−
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YKL089W YKL089W]  
+
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001572 YKL089W]  
 
|-
 
|-
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MIF2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MIF2 ''
Line 12: Line 13:
 
|-
 
|-
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
−
|nowrap| Chr XI:273038..274687
+
|nowrap| Chr XI:273394..275043
 
|-
 
|-
−
|colspan = '3'|{{Don'tEditThisBox}}
+
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001572
 
|}
 
|}
 
<br>
 
<br>
−
'''Description of {{PAGENAME}}:''' Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p<ref name='S000074553'>Westermann S, et al. (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22 {{SGDpaper|S000074553}} PMID 14581449</ref><ref name='S000053424'>Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 {{SGDpaper|S000053424}} PMID 7579695</ref><ref name='S000045933'>Brown MT, et al. (1993) MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J Cell Biol 123(2):387-403
+
'''Description of YKL089W:''' Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3<ref name='S000045933'>Brown MT, et al. (1993) MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J Cell Biol 123(2):387-403 {{SGDpaper|S000045933}} PMID 8408221</ref><ref name='S000053424'>Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 {{SGDpaper|S000053424}} PMID 7579695</ref><ref name='S000149670'>Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 {{SGDpaper|S000149670}} PMID 22561346</ref><ref name='S000074553'>Westermann S, et al. (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22
−
  {{SGDpaper|S000045933}} PMID 8408221</ref>
+
  {{SGDpaper|S000074553}} PMID 14581449</ref>
 
<br>
 
<br>
 
<br>
 
<br>
 
<br>
 
<br>
 
<br>
 
<br>
−
 
+
<br>
 +
</protect>
 
__TOC__
 
__TOC__
 
==Community Commentary==
 
==Community Commentary==
 
{{CommentaryHelp}}
 
{{CommentaryHelp}}
 +
=== Interactions ===
 +
[[Category:Topic:Interactions]]
 +
==== Genetic ====
 +
[[Category:Topic:Interactions:Genetic]]
 +
 +
'''Strain Background''': A364A/S288C<br>
 +
Genetic interaction with CBF2 [[Category:Genetic Interactions with CBF2]]<br>'''Phenotype(s)''': Synthetic Lethal with CBF2 [[Category:Phenotype:Synthetic Lethal with CBF2]]
 +
'''Mutation type(s)''': temperature sensitive missense
 +
 +
at the time showed that MIF2 genetically interacts with an "established" centromere protein gene <ref name='S000053424'>Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 {{SGDpaper|S000053424}} PMID 7579695</ref> <ref name = 'CAset3899-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3899 Pamela B. Meluh] on 2003-03-17</ref>
 +
 +
{{ShortCenteredHR}}
 +
==== Physical ====
 +
[[Category:Topic:Interactions:Physical]]
 +
Physical interaction with CSE4 [[Category:Physical Interactions with CSE4]]<br>
 +
Cse4p immunoprecipitates with Mif2p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
 +
 +
{{ShortCenteredHR}}
 +
Physical interaction with DSN1 [[Category:Physical Interactions with DSN1]]<br>
 +
Mif2p co-immunoprecipitates Dsn1p. <ref name='S000075182'>Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 {{SGDpaper|S000075182}} PMID 14602074</ref> <ref name = 'CAset9883-2004-03-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9883 Benjamin Pinsky] on 2004-03-04</ref>
 +
 +
{{ShortCenteredHR}}
 +
=== Protein Details ===
 +
[[Category:Topic:Protein Details]]
 +
==== Other Protein Details ====
 +
[[Category:Topic:Protein Details:Other Protein Details]]
 +
'''Other Topic''': Homology [[Category:Topic:Homology]]
 +
 +
MIF2 contains two regions of high sequence similarity to human CENP-C. <ref name='S000053424'>Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 {{SGDpaper|S000053424}} PMID 7579695</ref> <ref name = 'CAset3899-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=3899 Pamela B. Meluh] on 2003-03-17</ref>
 +
 +
{{ShortCenteredHR}}
 +
 +
 +
 +
<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
 +
<!--
 +
Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
 +
<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
 +
J Biol Chem 278(5):3265-74</ref>
 +
-->
 +
 +
  
 +
<protect>
 
==References==
 
==References==
 
<!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 
<!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 
{{RefHelp}}
 
{{RefHelp}}
 +
</protect>

Latest revision as of 13:05, 4 October 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YKL089W
Gene name MIF2
Aliases
Feature type ORF, Verified
Coordinates Chr XI:273394..275043
Primary SGDID S000001572


Description of YKL089W: Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3[1][2][3][4]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Interactions

Genetic

Strain Background: A364A/S288C
Genetic interaction with CBF2
Phenotype(s): Synthetic Lethal with CBF2 Mutation type(s): temperature sensitive missense

at the time showed that MIF2 genetically interacts with an "established" centromere protein gene [2] [5]

Physical

Physical interaction with CSE4
Cse4p immunoprecipitates with Mif2p. [6] [7]

Physical interaction with DSN1
Mif2p co-immunoprecipitates Dsn1p. [6] [7]

Protein Details

Other Protein Details

Other Topic: Homology

MIF2 contains two regions of high sequence similarity to human CENP-C. [2] [5]




<protect>

References

See Help:References on how to add references

  1. ↑ Brown MT, et al. (1993) MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J Cell Biol 123(2):387-403 SGD PMID 8408221
  2. ↑ 2.0 2.1 2.2 Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 SGD PMID 7579695
  3. ↑ Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
  4. ↑ Westermann S, et al. (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22 SGD PMID 14581449
  5. ↑ 5.0 5.1 submitted by Pamela B. Meluh on 2003-03-17
  6. ↑ 6.0 6.1 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  7. ↑ 7.0 7.1 submitted by Benjamin Pinsky on 2004-03-04

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

Retrieved from "https://wiki.yeastgenome.org/index.php?title=YKL089W&oldid=394514"