Difference between revisions of "YFL036W"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001858 YFL036W] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPO41 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPO41 '' | ||
| Line 18: | Line 18: | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YFL036W:''' Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition | + | '''Description of YFL036W:''' Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation<ref name='S000050238'>Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 {{SGDpaper|S000050238}} PMID 3517858</ref><ref name='S000146745'>Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () {{SGDpaper|S000146745}} PMID 21911502</ref><ref name='S000149299'>Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () |
| − | {{SGDpaper| | + | {{SGDpaper|S000149299}} PMID 22524540</ref> |
<br> | <br> | ||
<br> | <br> | ||
Latest revision as of 13:05, 9 May 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFL036W |
| Gene name | RPO41 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:58782..62837 |
| Primary SGDID | S000001858 |
Description of YFL036W: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation[1][2][3]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Interactions
Two Hybrid
Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [4] [5]
Protein Details
Protein Function/Process
The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [6] [7]
<protect>
References
See Help:References on how to add references
- ↑ Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 SGD PMID 3517858
- ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
- ↑ Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () SGD PMID 22524540
- ↑ Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
- ↑ submitted by Gerald Shadel on 2003-06-05
- ↑ Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 SGD PMID 10393945
- ↑ submitted by Gerald Shadel on 2003-06-06
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
