Difference between revisions of "YDR422C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR422C YDR422C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002830 YDR422C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SIP1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SIP1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:1317765..1315318
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|nowrap| Chr IV:1317773..1315326
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002830
 
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'''Description of {{PAGENAME}}:''' Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions<ref name='S000073587'>Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 {{SGDpaper|S000073587}} PMID 12715202</ref><ref name='S000060188'>Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14 {{SGDpaper|S000060188}} PMID 11331606</ref><ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43
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'''Description of YDR422C:''' Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions<ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref><ref name='S000073587'>Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 {{SGDpaper|S000073587}} PMID 12715202</ref><ref name='S000060188'>Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14
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{{SGDpaper|S000059161}} PMID 10990457</ref>
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{{SGDpaper|S000060188}} PMID 11331606</ref>
 
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__TOC__
 
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==Community Commentary==
 
==Community Commentary==
 
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=== Alleles, Strains, and Phenotypes ===
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[[Category:Topic:Alleles, Strains, and Phenotypes]]
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==== Multiple Knockout Strains ====
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[[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
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'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
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'''Genotype''': MCY4581<br>
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'''Together with''': NRG2, NRG1, GAL83, SIP2<br>
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
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Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
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'''Genotype''': MCY4600<br>
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'''Together with''': REG1, GAL83, SIP2, MUC1<br>
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
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Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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{{ShortCenteredHR}}
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'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
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'''Genotype''': MCY4600<br>
 +
'''Together with''': REG1, GAL83, SIP2, MUC1<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
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Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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{{ShortCenteredHR}}
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'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
 +
'''Genotype''': MCY4581<br>
 +
'''Together with''': NRG2, NRG1, GAL83, SIP2<br>
 +
'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
 +
 +
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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{{ShortCenteredHR}}
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=== Protein Details ===
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[[Category:Topic:Protein Details]]
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==== Protein Function/Process ====
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[[Category:Topic:Protein Details:Protein Function/Process]]
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One of three alternative beta subunits of the Snf1 kinase complex <ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref> <ref name = 'CAset5180-2003-02-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5180 Martin C. Schmidt] on 2003-02-17</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YDR422C
Gene name SIP1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1317773..1315326
Primary SGDID S000002830


Description of YDR422C: Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions[1][2][3]




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Community Commentary

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Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, GAL83, SIP2
Phenotype(s): Loss of function (Null)

Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [4] [5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [4] [5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [4] [5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, GAL83, SIP2
Phenotype(s): Loss of function (Null)

Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [4] [5]

Protein Details

Protein Function/Process

One of three alternative beta subunits of the Snf1 kinase complex [1] [6]




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References

See Help:References on how to add references

  1. ↑ 1.0 1.1 Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
  2. ↑ Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 SGD PMID 12715202
  3. ↑ Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14 SGD PMID 11331606
  4. ↑ 4.0 4.1 4.2 4.3 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
  5. ↑ 5.0 5.1 5.2 5.3 submitted by Valmik K. Vyas on 2003-03-27
  6. ↑ submitted by Martin C. Schmidt on 2003-02-17

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