YDR422C
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| Systematic name | YDR422C |
| Gene name | SIP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1317773..1315326 |
| Primary SGDID | S000002830 |
Description of YDR422C: Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions[1][2][3]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [4] [5]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [4] [5]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [4] [5]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [4] [5]
Protein Details
Protein Function/Process
One of three alternative beta subunits of the Snf1 kinase complex [1] [6]
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References
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- ↑ 1.0 1.1 Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
- ↑ Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 SGD PMID 12715202
- ↑ Vincent O, et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15(9):1104-14 SGD PMID 11331606
- ↑ 4.0 4.1 4.2 4.3 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ 5.0 5.1 5.2 5.3 submitted by Valmik K. Vyas on 2003-03-27
- ↑ submitted by Martin C. Schmidt on 2003-02-17
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