Difference between revisions of "YDR227W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR227W YDR227W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002635 YDR227W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SIR4 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SIR4 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:917567..921643
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|nowrap| Chr IV:917571..921647
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002635
 
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'''Description of {{PAGENAME}}:''' Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000051211'>Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 {{SGDpaper|S000051211}} PMID 9122169</ref><ref name='S000043531'>Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96
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'''Description of YDR227W:''' Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan<ref name='S000043531'>Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96 {{SGDpaper|S000043531}} PMID 7859289</ref><ref name='S000051211'>Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 {{SGDpaper|S000051211}} PMID 9122169</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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==Community Commentary==
 
==Community Commentary==
 
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with UBP10 [[Category:Two Hybrid Interactions with UBP10]]<br>
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The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). <ref name='S000042118'>Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 {{SGDpaper|S000042118}} PMID 10490600</ref> <ref name = 'CAset2117-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2117 Daniel E. Gottschling] on 2003-03-17</ref>
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=== Protein Details ===
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==== Protein Modification ====
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[[Category:Topic:Protein Details:Protein Modification]]
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-21'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-21</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YDR227W
Gene name SIR4
Aliases ASD1, STE9, UTH2
Feature type ORF, Verified
Coordinates Chr IV:917571..921647
Primary SGDID S000002635


Description of YDR227W: Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan[1][2][3]




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Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with UBP10
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [4] [5]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [6]




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References

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  1. ↑ Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96 SGD PMID 7859289
  2. ↑ Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 SGD PMID 9122169
  3. ↑ 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  4. ↑ Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600
  5. ↑ submitted by Daniel E. Gottschling on 2003-03-17
  6. ↑ submitted by Jeff Ubersax on 2004-01-21

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