Difference between revisions of "YER027C"
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{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000829 YER027C] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''GAL83 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''GAL83 '' | ||
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|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
− | |nowrap| Chr V: | + | |nowrap| Chr V:210232..208979 |
|- | |- | ||
− | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000829 |
|} | |} | ||
<br> | <br> | ||
− | '''Description of | + | '''Description of YER027C:''' One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain<ref name='S000073587'>Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 {{SGDpaper|S000073587}} PMID 12715202</ref><ref name='S000074696'>Wiatrowski HA, et al. (2004) Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Mol Cell Biol 24(1):352-61 |
− | + | {{SGDpaper|S000074696}} PMID 14673168</ref> | |
<br> | <br> | ||
<br> | <br> | ||
<br> | <br> | ||
<br> | <br> | ||
+ | <br> | ||
+ | </protect> | ||
+ | __TOC__ | ||
+ | ==Community Commentary== | ||
+ | {{CommentaryHelp}} | ||
=== Alleles, Strains, and Phenotypes === | === Alleles, Strains, and Phenotypes === | ||
[[Category:Topic:Alleles, Strains, and Phenotypes]] | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
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− | + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | |
− | + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | |
+ | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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+ | </protect> |
Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YER027C |
Gene name | GAL83 |
Aliases | SPM1 |
Feature type | ORF, Verified |
Coordinates | Chr V:210232..208979 |
Primary SGDID | S000000829 |
Description of YER027C: One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain[1][2]
</protect>
Contents
[hide]Community Commentary
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Complete Deletion
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Protein Details
Protein Function/Process
One of three alternative beta subunits of the Snf1 kinase complex [5] [6]
<protect>
References
See Help:References on how to add references
- Jump up ↑ Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 SGD PMID 12715202
- Jump up ↑ Wiatrowski HA, et al. (2004) Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Mol Cell Biol 24(1):352-61 SGD PMID 14673168
- ↑ Jump up to: 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ Jump up to: 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 submitted by Valmik K. Vyas on 2003-03-27
- Jump up ↑ Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
- Jump up ↑ submitted by Martin C. Schmidt on 2003-02-17
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