Difference between revisions of "YCR084C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YCR084C YCR084C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000680 YCR084C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TUP1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TUP1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr III:262449..260308
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|nowrap| Chr III:262452..260311
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000680
 
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'''Description of {{PAGENAME}}:''' General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes<ref name='S000062263'>Conlan RS, et al. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator. J Biol Chem 274(1):205-10 {{SGDpaper|S000062263}} PMID 9867831</ref><ref name='S000055359'>Keleher CA, et al. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68(4):709-19 {{SGDpaper|S000055359}} PMID 1739976</ref><ref name='S000054896'>Zhang L and Guarente L (1994) Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. Genetics 136(3):813-7 {{SGDpaper|S000054896}} PMID 8005436</ref><ref name='S000054654'>Williams FE, et al. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol Cell Biol 11(6):3307-16 {{SGDpaper|S000054654}} PMID 2038333</ref><ref name='S000054259'>Cooper JP, et al. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev 8(12):1400-10 {{SGDpaper|S000054259}} PMID 7926740</ref><ref name='S000039585'>Edmondson DG, et al. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10(10):1247-59
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'''Description of YCR084C:''' General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes<ref name='S000062263'>Conlan RS, et al. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator. J Biol Chem 274(1):205-10 {{SGDpaper|S000062263}} PMID 9867831</ref><ref name='S000054259'>Cooper JP, et al. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev 8(12):1400-10 {{SGDpaper|S000054259}} PMID 7926740</ref><ref name='S000039585'>Edmondson DG, et al. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10(10):1247-59 {{SGDpaper|S000039585}} PMID 8675011</ref><ref name='S000055359'>Keleher CA, et al. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68(4):709-19 {{SGDpaper|S000055359}} PMID 1739976</ref><ref name='S000054654'>Williams FE, et al. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol Cell Biol 11(6):3307-16 {{SGDpaper|S000054654}} PMID 2038333</ref><ref name='S000054896'>Zhang L and Guarente L (1994) Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. Genetics 136(3):813-7
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==Community Commentary==
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=== DNA and RNA Details ===
 
=== DNA and RNA Details ===
 
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==== Other DNA and RNA Details ====
 
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'''Other Topic''': expression [[Category:Topic:expression]]
 
  
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Specifically lower expression in carbon limited chemostat cultures versus carbon excess. <ref name='S000073646'>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 {{SGDpaper|S000073646}} PMID 12414795</ref> <ref name = 'CAset9153-2003-07-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9153 Viktor Boer] on 2003-07-25</ref>
 
  
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=== Interactions ===
 
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'''Other Topic''': functional dependence [[Category:Topic:functional dependence]]
 
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Other Interactions interaction with Nrg1 [[Category:Other Interactions Interactions with Nrg1]]<br>
 
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Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Tup1. <ref name='S000053650'>Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 {{SGDpaper|S000053650}} PMID 10022891</ref> <ref name = 'CAset6176-2003-02-12'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-12</ref>
 
  
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YCR084C
Gene name TUP1
Aliases AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7
Feature type ORF, Verified
Coordinates Chr III:262452..260311
Primary SGDID S000000680


Description of YCR084C: General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes[1][2][3][4][5][6]




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Community Commentary

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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in carbon limited chemostat cultures versus carbon excess. [7] [8]

Interactions

Other Interactions

Other Topic: functional dependence Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Tup1. [9] [10]




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References

See Help:References on how to add references

  1. ↑ Conlan RS, et al. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator. J Biol Chem 274(1):205-10 SGD PMID 9867831
  2. ↑ Cooper JP, et al. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev 8(12):1400-10 SGD PMID 7926740
  3. ↑ Edmondson DG, et al. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10(10):1247-59 SGD PMID 8675011
  4. ↑ Keleher CA, et al. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68(4):709-19 SGD PMID 1739976
  5. ↑ Williams FE, et al. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol Cell Biol 11(6):3307-16 SGD PMID 2038333
  6. ↑ Zhang L and Guarente L (1994) Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. Genetics 136(3):813-7 SGD PMID 8005436
  7. ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. ↑ submitted by Viktor Boer on 2003-07-25
  9. ↑ Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
  10. ↑ submitted by Valmik K. Vyas on 2003-02-12

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