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Systematic name YCR084C
Gene name TUP1
Aliases AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7
Feature type ORF, Verified
Coordinates Chr III:262452..260311
Primary SGDID S000000680

Description of YCR084C: General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes[1][2][3][4][5][6]


Community Commentary

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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in carbon limited chemostat cultures versus carbon excess. [7] [8]


Other Interactions

Other Topic: functional dependence Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Tup1. [9] [10]



See Help:References on how to add references

  1. Conlan RS, et al. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator. J Biol Chem 274(1):205-10 SGD PMID 9867831
  2. Cooper JP, et al. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev 8(12):1400-10 SGD PMID 7926740
  3. Edmondson DG, et al. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10(10):1247-59 SGD PMID 8675011
  4. Keleher CA, et al. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68(4):709-19 SGD PMID 1739976
  5. Williams FE, et al. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol Cell Biol 11(6):3307-16 SGD PMID 2038333
  6. Zhang L and Guarente L (1994) Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. Genetics 136(3):813-7 SGD PMID 8005436
  7. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. submitted by Viktor Boer on 2003-07-25
  9. Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
  10. submitted by Valmik K. Vyas on 2003-02-12

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