Difference between revisions of "YBR246W"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000450 YBR246W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RRT2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RRT2 '' |
Revision as of 07:45, 23 January 2012
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Systematic name | YBR246W |
Gene name | RRT2 |
Aliases | ERE1 |
Feature type | ORF, Verified |
Coordinates | Chr II:711591..712754 |
Primary SGDID | S000000450 |
Description of YBR246W: Diphthamide synthetase; required for last step of diphthamide biosynthesis, deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription[1][2][3][4]
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Contents
Community Commentary
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References
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- ↑ Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 SGD PMID 12134085
- ↑ Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 SGD PMID 19270272
- ↑ Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () SGD PMID 21880895
- ↑ Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc () SGD PMID 22188241
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