Difference between revisions of "YML034W"

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'''Description of YML034W:''' Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; possible role in chromatid segregation<ref name='S000127665'>Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 {{SGDpaper|S000127665}} PMID 18762579</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000123937'>King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 {{SGDpaper|S000123937}} PMID 16929305</ref><ref name='S000069006'>Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 {{SGDpaper|S000069006}} PMID 11754482</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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'''Description of YML034W:''' Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; mutant has aneuploidy tolerance<ref name='S000127665'>Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 {{SGDpaper|S000127665}} PMID 18762579</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000123937'>King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 {{SGDpaper|S000123937}} PMID 16929305</ref><ref name='S000069006'>Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 {{SGDpaper|S000069006}} PMID 11754482</ref><ref name='S000136872'>Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 {{SGDpaper|S000136872}} PMID 20850176</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Revision as of 14:05, 11 January 2011

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Systematic name YML034W
Gene name SRC1
Aliases HEH1, YML033W
Feature type ORF, Verified
Coordinates Chr XIII:209525..212155
Primary SGDID S000004497


Description of YML034W: Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; mutant has aneuploidy tolerance[1][2][3][4][5][6]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]





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References

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  1. Grund SE, et al. (2008) The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression. J Cell Biol 182(5):897-910 SGD PMID 18762579
  2. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  3. King MC, et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7 SGD PMID 16929305
  4. Rodriguez-Navarro S, et al. (2002) SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Yeast 19(1):43-54 SGD PMID 11754482
  5. Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176
  6. 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  7. submitted by Jeff Ubersax on 2004-01-29

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