Difference between revisions of "YNL118C"

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=== DNA and RNA Details ===
 
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[[Category:Topic:DNA and RNA Details]]
 
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==== RNA Degradation ====
 
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[[Category:Topic:DNA and RNA Details:RNA Degradation]]
 
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Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref>
 
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=== Interactions ===
 
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[[Category:Topic:Interactions]]
 
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==== Two Hybrid ====
 
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[[Category:Topic:Interactions:Two Hybrid]]
 
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Two Hybrid interaction with NAM7 [[Category:Two Hybrid Interactions with NAM7]]<br>
 
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Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins <ref name='S000042824'>He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 {{SGDpaper|S000042824}} PMID 7883168</ref> <ref name = 'CAset9314-2003-04-30'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9314 Jurgen Wittmann] on 2003-04-30</ref>
 
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=== Protein Details ===
 
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[[Category:Topic:Protein Details]]
 
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==== Nucleic Acid Binding ====
 
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[[Category:Topic:Protein Details:Nucleic Acid Binding]]
 
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YNL118C binds RNA [[Category:Binds RNA]]
 
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Interacts with substrate mRNA to cleave cap structure but not with free cap. <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref>
 
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==== Other Protein Details ====
 
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[[Category:Topic:Protein Details:Other Protein Details]]
 
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'''Other Topic''': Motif [[Category:Topic:Motif]]
 
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Contains a MUT T/NUDIX motif as well as other specific conserved regions <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref>
 
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=== Techniques and Reagents ===
 
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[[Category:Topic:Techniques and Reagents]]
 
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==== Protein Purification ====
 
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[[Category:Topic:Techniques and Reagents:Protein Purification]]
 
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Recombinant protein (truncated) <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref>
 
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==Community Commentary==
 
==Community Commentary==

Revision as of 10:51, 24 January 2007

Share your knowledge...Edit this entry!

Systematic name YNL118C
Gene name DCP2
Aliases PSU1
Feature type ORF, Verified
Coordinates Chr XIV:405566..402654
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Description of YNL118C: Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family[1][2][3]



Community Commentary

About Community Commentary. Please share your knowledge!

DNA and RNA Details

RNA Degradation

Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs [4] [5]

Interactions

Two Hybrid

Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [6] [7]

Protein Details

Nucleic Acid Binding

YNL118C binds RNA Interacts with substrate mRNA to cleave cap structure but not with free cap. [4] [5]

Other Protein Details

Other Topic: Motif

Contains a MUT T/NUDIX motif as well as other specific conserved regions [4] [5]

Techniques and Reagents

Protein Purification

Recombinant protein (truncated) [4] [5]

References

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  1. ↑ She M, et al. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70 SGD PMID 16341225
  2. ↑ Dunckley T, et al. (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37 SGD PMID 11139489
  3. ↑ Gaudon C, et al. (1999) Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 18(8):2229-40 SGD PMID 10205176
  4. ↑ 4.0 4.1 4.2 4.3 van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 SGD PMID 12486012
  5. ↑ 5.0 5.1 5.2 5.3 submitted by Bertrand Seraphin on 2003-09-03
  6. ↑ He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
  7. ↑ submitted by Jurgen Wittmann on 2003-04-30

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