Difference between revisions of "YJL187C"

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=== Alleles, Strains, and Phenotypes ===
 
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[[Category:Topic:Alleles, Strains, and Phenotypes]]
 
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==== Complete Deletion ====
 
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[[Category:Topic:Alleles, Strains, and Phenotypes:Complete Deletion]]
 
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'''Strain Background''': W303<br>
 
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'''Genotype''': SH24: swe1::URA3 bar1<br>
 
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Premature entry into mitosis [[Category:Phenotype:Premature entry into mitosis]], Viable [[Category:Phenotype:Viable]]
 
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Despite previous reports to the contrary, swe1 mutant cells enter mitosis prematurely at a reduced bud size. <ref name='S000074153'>Harvey SL and Kellogg DR (2003) Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr Biol 13(4):264-75 {{SGDpaper|S000074153}} PMID 12593792</ref> <ref name = 'CAset10733-2005-06-08'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=10733 Stacy Harvey] on 2005-06-08</ref>
 
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{{ShortCenteredHR}}
 
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==== Point Mutation ====
 
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[[Category:Topic:Alleles, Strains, and Phenotypes:Point Mutation]]
 
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'''Strain Background''': BF264-15D<br>
 
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'''Phenotype(s)''': Dominant [[Category:Phenotype:Dominant]], stabilized [[Category:Phenotype:stabilized]]
 
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Deletion or mutation of residues between Leu320 and Tyr332 stabilizes Swe1p. <ref name='S000071520'>McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 {{SGDpaper|S000071520}} PMID 12388757</ref> <ref name = 'CAset7236-2003-03-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7236 Daniel Lew] on 2003-03-03</ref>
 
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=== Interactions ===
 
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[[Category:Topic:Interactions]]
 
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==== Other Interactions ====
 
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[[Category:Topic:Interactions:Other Interactions]]
 
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'''Other Topic''': NOT Regulatory [[Category:Topic:NOT Regulatory]]
 
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Other Interactions interaction with MET30 [[Category:Other Interactions Interactions with MET30]]<br>
 
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Despite previous reports to the contrary, Met30p is not required for Swe1p degradation <ref name='S000071520'>McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 {{SGDpaper|S000071520}} PMID 12388757</ref> <ref name = 'CAset7236-2003-03-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7236 Daniel Lew] on 2003-03-03</ref>
 
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=== Other ===
 
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[[Category:Topic:Other]]
 
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==== Localization ====
 
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[[Category:Topic:Other:Localization]]
 
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Swe1p localization to the neck abolished by mutations in residues Leu320, Leu324, Phe327, Lys328,Leu331, or Tyr332 <ref name='S000071520'>McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 {{SGDpaper|S000071520}} PMID 12388757</ref> <ref name = 'CAset7236-2003-03-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7236 Daniel Lew] on 2003-03-03</ref>
 
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=== Protein Details ===
 
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[[Category:Topic:Protein Details]]
 
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==== Protein Modification ====
 
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[[Category:Topic:Protein Details:Protein Modification]]
 
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
 
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==Community Commentary==
 
==Community Commentary==

Revision as of 10:51, 24 January 2007

Share your knowledge...Edit this entry!

Systematic name YJL187C
Gene name SWE1
Aliases WEE1
Feature type ORF, Verified
Coordinates Chr X:79261..76802
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Description of YJL187C: Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate[1][2][3]



Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Complete Deletion

Strain Background: W303
Genotype: SH24: swe1::URA3 bar1
Phenotype(s): Loss of function (Null), Premature entry into mitosis, Viable

Despite previous reports to the contrary, swe1 mutant cells enter mitosis prematurely at a reduced bud size. [4] [5]

Point Mutation

Strain Background: BF264-15D
Phenotype(s): Dominant, stabilized

Deletion or mutation of residues between Leu320 and Tyr332 stabilizes Swe1p. [6] [7]

Interactions

Other Interactions

Other Topic: NOT Regulatory Other Interactions interaction with MET30
Despite previous reports to the contrary, Met30p is not required for Swe1p degradation [6] [7]

Other

Localization

Swe1p localization to the neck abolished by mutations in residues Leu320, Leu324, Phe327, Lys328,Leu331, or Tyr332 [6] [7]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [8]

References

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  1. ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  2. ↑ Longtine MS, et al. (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61 SGD PMID 10805747
  3. ↑ Booher RN, et al. (1993) Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J 12(9):3417-26 SGD PMID 8253069
  4. ↑ Harvey SL and Kellogg DR (2003) Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr Biol 13(4):264-75 SGD PMID 12593792
  5. ↑ submitted by Stacy Harvey on 2005-06-08
  6. ↑ 6.0 6.1 6.2 McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 SGD PMID 12388757
  7. ↑ 7.0 7.1 7.2 submitted by Daniel Lew on 2003-03-03
  8. ↑ submitted by Jeff Ubersax on 2004-01-27

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