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| − | === Alleles, Strains, and Phenotypes ===
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| − | [[Category:Topic:Alleles, Strains, and Phenotypes]]
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| − | ==== Multiple Knockout Strains ====
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| − | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
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| − |
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| − | '''Strain Background''': Sigma1278b<br>
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| − | '''Genotype''': MCY4461<br>
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| − | '''Together with''': REG1<br>
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| − | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
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| − |
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| − | Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | === Interactions ===
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| − | [[Category:Topic:Interactions]]
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| − | ==== Genetic ====
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| − | [[Category:Topic:Interactions:Genetic]]
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| − | YDR477W is suppressed by Nrg2 [[Category:Genetic Interaction with Nrg2]]
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| − |
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| − |
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| − | '''Strain Background''': Sigma 1278b<br>
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| − | '''Mutation type(s)''': complete deletion, complete deletion
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| − |
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| − | Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | YDR477W is suppressed by Nrg1 [[Category:Genetic Interaction with Nrg1]]
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| − |
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| − |
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| − | '''Strain Background''': Sigma 1278b<br>
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| − | '''Mutation type(s)''': complete deletion, complete deletion
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| − |
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| − | Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | ==== Physical ====
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| − | [[Category:Topic:Interactions:Physical]]
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| − | Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br>
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| − | Snf1 coimmunoprecipitates with HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br>
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| − | LexA-Snf1 coimmunoprecipitates HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br>
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| − | Snf1 coimmunoprecipitates with HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br>
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| − | LexA-Snf1 coimmunoprecipitates HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | ==== Two Hybrid ====
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| − | [[Category:Topic:Interactions:Two Hybrid]]
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| − | Two Hybrid interaction with Nrg2 [[Category:Two Hybrid Interactions with Nrg2]]<br>
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| − | Snf1 kinase domain interacts with Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Two Hybrid interaction with nrg1 [[Category:Two Hybrid Interactions with nrg1]]<br>
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| − | Snf1 kinase domain interacts with Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| | __TOC__ | | __TOC__ |
| | ==Community Commentary== | | ==Community Commentary== |
Share your knowledge...Edit this entry!
| Systematic name |
YDR477W
|
| Gene name |
SNF1
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| Aliases |
CAT1, CCR1, GLC2, HAF3, PAS14
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| Feature type |
ORF, Verified
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| Coordinates
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Chr IV:1412365..1414266
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| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs.
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Description of YDR477W: AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis[1][2]
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)
Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]
Interactions
Genetic
YDR477W is suppressed by Nrg2
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]
YDR477W is suppressed by Nrg1
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]
Physical
Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]
Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]
Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]
Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]
Two Hybrid
Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]
Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]
References
See Help:References on how to add references
- ↑ Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 SGD PMID 9759505
- ↑ Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81
SGD PMID 12546680
- ↑ 3.0 3.1 3.2 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013
- ↑ submitted by Valmik K. Vyas on 2003-03-27
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 submitted by Valmik K. Vyas on 2003-02-04
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 SGD PMID 11404322
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