Difference between revisions of "YNL118C"
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| + | === DNA and RNA Details === | ||
| + | [[Category:Topic:DNA and RNA Details]] | ||
| + | ==== RNA Degradation ==== | ||
| + | [[Category:Topic:DNA and RNA Details:RNA Degradation]] | ||
| + | Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Two Hybrid ==== | ||
| + | [[Category:Topic:Interactions:Two Hybrid]] | ||
| + | Two Hybrid interaction with NAM7 [[Category:Two Hybrid Interactions with NAM7]]<br> | ||
| + | Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins <ref name='S000042824'>He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 {{SGDpaper|S000042824}} PMID 7883168</ref> <ref name = 'CAset9314-2003-04-30'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9314 Jurgen Wittmann] on 2003-04-30</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Nucleic Acid Binding ==== | ||
| + | [[Category:Topic:Protein Details:Nucleic Acid Binding]] | ||
| + | YNL118C binds RNA [[Category:Binds RNA]] | ||
| + | Interacts with substrate mRNA to cleave cap structure but not with free cap. <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Other Protein Details ==== | ||
| + | [[Category:Topic:Protein Details:Other Protein Details]] | ||
| + | '''Other Topic''': Motif [[Category:Topic:Motif]] | ||
| + | |||
| + | Contains a MUT T/NUDIX motif as well as other specific conserved regions <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Techniques and Reagents === | ||
| + | [[Category:Topic:Techniques and Reagents]] | ||
| + | ==== Protein Purification ==== | ||
| + | [[Category:Topic:Techniques and Reagents:Protein Purification]] | ||
| + | |||
| + | Recombinant protein (truncated) <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === DNA and RNA Details === | ||
| + | [[Category:Topic:DNA and RNA Details]] | ||
| + | ==== RNA Degradation ==== | ||
| + | [[Category:Topic:DNA and RNA Details:RNA Degradation]] | ||
| + | |||
| + | Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Two Hybrid ==== | ||
| + | [[Category:Topic:Interactions:Two Hybrid]] | ||
| + | Two Hybrid interaction with NAM7 [[Category:Two Hybrid Interactions with NAM7]]<br> | ||
| + | Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins <ref name='S000042824'>He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 {{SGDpaper|S000042824}} PMID 7883168</ref> <ref name = 'CAset9314-2003-04-30'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9314 Jurgen Wittmann] on 2003-04-30</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Nucleic Acid Binding ==== | ||
| + | [[Category:Topic:Protein Details:Nucleic Acid Binding]] | ||
| + | YNL118C binds RNA [[Category:Binds RNA]] | ||
| + | Interacts with substrate mRNA to cleave cap structure but not with free cap. <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Other Protein Details ==== | ||
| + | [[Category:Topic:Protein Details:Other Protein Details]] | ||
| + | '''Other Topic''': Motif [[Category:Topic:Motif]] | ||
| + | |||
| + | Contains a MUT T/NUDIX motif as well as other specific conserved regions <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Techniques and Reagents === | ||
| + | [[Category:Topic:Techniques and Reagents]] | ||
| + | ==== Protein Purification ==== | ||
| + | [[Category:Topic:Techniques and Reagents:Protein Purification]] | ||
| + | |||
| + | Recombinant protein (truncated) <ref name='S000073817'>van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 {{SGDpaper|S000073817}} PMID 12486012</ref> <ref name = 'CAset5281-2003-09-03'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5281 Bertrand Seraphin] on 2003-09-03</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 16:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YNL118C | |
| Gene name | DCP2 | |
| Aliases | PSU1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XIV:405566..402654 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YNL118C: Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family[1][2][3]
DNA and RNA Details
RNA Degradation
Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs [4] [5]
Interactions
Two Hybrid
Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [6] [7]
Protein Details
Nucleic Acid Binding
YNL118C binds RNA Interacts with substrate mRNA to cleave cap structure but not with free cap. [4] [5]
Other Protein Details
Other Topic: Motif
Contains a MUT T/NUDIX motif as well as other specific conserved regions [4] [5]
Techniques and Reagents
Protein Purification
Recombinant protein (truncated) [4] [5]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
DNA and RNA Details
RNA Degradation
Yeast Dcp2 is catalitically active to cleave the cap structure of mRNAs [4] [5]
Interactions
Two Hybrid
Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [6] [7]
Protein Details
Nucleic Acid Binding
YNL118C binds RNA Interacts with substrate mRNA to cleave cap structure but not with free cap. [4] [5]
Other Protein Details
Other Topic: Motif
Contains a MUT T/NUDIX motif as well as other specific conserved regions [4] [5]
Techniques and Reagents
Protein Purification
Recombinant protein (truncated) [4] [5]
References
See Help:References on how to add references
- ↑ She M, et al. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70 SGD PMID 16341225
- ↑ Dunckley T, et al. (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37 SGD PMID 11139489
- ↑ Gaudon C, et al. (1999) Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 18(8):2229-40 SGD PMID 10205176
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 van Dijk E, et al. (2002) Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J 21(24):6915-24 SGD PMID 12486012
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 submitted by Bertrand Seraphin on 2003-09-03
- ↑ 6.0 6.1 He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
- ↑ 7.0 7.1 submitted by Jurgen Wittmann on 2003-04-30
See Help:Categories on how to add the wiki page for this gene to a Category
Categories:
- ORF
- ORF, Verified
- Topic:DNA and RNA Details
- Topic:DNA and RNA Details:RNA Degradation
- Topic:Interactions
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with NAM7
- Topic:Protein Details
- Topic:Protein Details:Nucleic Acid Binding
- Binds RNA
- Topic:Protein Details:Other Protein Details
- Topic:Motif
- Topic:Techniques and Reagents
- Topic:Techniques and Reagents:Protein Purification
