Difference between revisions of "YFL036W"

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=== Interactions ===
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with MTF2 [[Category:Two Hybrid Interactions with MTF2]]<br>
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The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. <ref name='S000060339'>Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 {{SGDpaper|S000060339}} PMID 11118450</ref> <ref name = 'CAset5293-2003-06-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-05</ref>
  
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=== Protein Details ===
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[[Category:Topic:Protein Details]]
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==== Protein Function/Process ====
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[[Category:Topic:Protein Details:Protein Function/Process]]
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The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. <ref name='S000073224'>Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 {{SGDpaper|S000073224}} PMID 10393945</ref> <ref name = 'CAset5293-2003-06-06'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-06</ref>
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==Community Commentary==
 
==Community Commentary==
 
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with MTF2 [[Category:Two Hybrid Interactions with MTF2]]<br>
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The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. <ref name='S000060339'>Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 {{SGDpaper|S000060339}} PMID 11118450</ref> <ref name = 'CAset5293-2003-06-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-05</ref>
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{{ShortCenteredHR}}
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=== Protein Details ===
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[[Category:Topic:Protein Details]]
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==== Protein Function/Process ====
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[[Category:Topic:Protein Details:Protein Function/Process]]
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The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. <ref name='S000073224'>Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 {{SGDpaper|S000073224}} PMID 10393945</ref> <ref name = 'CAset5293-2003-06-06'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-06</ref>
  
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==References==
 
==References==
 
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Revision as of 16:05, 23 January 2007

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Systematic name YFL036W
Gene name RPO41
Aliases
Feature type ORF, Verified
Coordinates Chr VI:58781..62836
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Description of YFL036W: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition[1][2]



Interactions

Two Hybrid

Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [3] [4]

Protein Details

Protein Function/Process

The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [5] [6]

Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [3] [4]

Protein Details

Protein Function/Process

The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [5] [6]

References

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  1. ↑ Costanzo MC and Fox TD (1990) Control of mitochondrial gene expression in Saccharomyces cerevisiae. Annu Rev Genet 24():91-113 SGD PMID 2088182
  2. ↑ Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 SGD PMID 3517858
  3. ↑ 3.0 3.1 Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
  4. ↑ 4.0 4.1 submitted by Gerald Shadel on 2003-06-05
  5. ↑ 5.0 5.1 Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 SGD PMID 10393945
  6. ↑ 6.0 6.1 submitted by Gerald Shadel on 2003-06-06

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