Difference between revisions of "YER027C"
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+ | === Alleles, Strains, and Phenotypes === | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
+ | ==== Complete Deletion ==== | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes:Complete Deletion]] | ||
+ | '''Allele''': gal83delta<br> | ||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in adherance to plastic in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in invasive growth in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in adherance to plastic in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83 delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants exhibit wild-type filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in invasive growth in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83 delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants exhibit wild-type filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | ==== Multiple Knockout Strains ==== | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]] | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4708<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4716<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4581<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4712<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4581<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4716<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4708<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4600<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4571<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4633<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4600<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4571<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4633<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4712<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | === Protein Details === | ||
+ | [[Category:Topic:Protein Details]] | ||
+ | ==== Protein Function/Process ==== | ||
+ | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
+ | |||
+ | One of three alternative beta subunits of the Snf1 kinase complex <ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref> <ref name = 'CAset5180-2003-02-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5180 Martin C. Schmidt] on 2003-02-17</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
+ | === Alleles, Strains, and Phenotypes === | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
+ | ==== Complete Deletion ==== | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes:Complete Deletion]] | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in adherance to plastic in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in invasive growth in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in adherance to plastic in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83 delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants exhibit wild-type filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b<br> | ||
+ | '''Genotype''': MCY4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants are defective in invasive growth in response to limiting glucose. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | '''Allele''': gal83 delta<br> | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4567<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | gal83 mutants exhibit wild-type filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | ==== Multiple Knockout Strains ==== | ||
+ | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]] | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4708<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4716<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4581<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4712<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4581<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY 4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4716<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4708<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4600<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4571<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4633<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4600<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma2000 series)<br> | ||
+ | '''Genotype''': MCY4571<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4633<br> | ||
+ | '''Together with''': REG1, SIP1, SIP2, MUC1<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4712<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | |||
+ | '''Strain Background''': Sigma1278b (Sigma 2000 series)<br> | ||
+ | '''Genotype''': MCY4597<br> | ||
+ | '''Together with''': NRG2, NRG1, SIP1, SIP2<br> | ||
+ | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
+ | |||
+ | sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
+ | |||
+ | {{ShortCenteredHR}} | ||
+ | === Protein Details === | ||
+ | [[Category:Topic:Protein Details]] | ||
+ | ==== Protein Function/Process ==== | ||
+ | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
+ | |||
+ | One of three alternative beta subunits of the Snf1 kinase complex <ref name='S000059161'>Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 {{SGDpaper|S000059161}} PMID 10990457</ref> <ref name = 'CAset5180-2003-02-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5180 Martin C. Schmidt] on 2003-02-17</ref> | ||
+ | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
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Revision as of 16:05, 23 January 2007
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Systematic name | YER027C | |
Gene name | GAL83 | |
Aliases | SPM1 | |
Feature type | ORF, Verified | |
Coordinates | Chr V:210231..208978 | |
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Description of YER027C: One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain[1][2]
Alleles, Strains, and Phenotypes
Complete Deletion
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Protein Details
Protein Function/Process
One of three alternative beta subunits of the Snf1 kinase complex [5] [6]
Contents
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Alleles, Strains, and Phenotypes
Complete Deletion
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in adherance to plastic in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Allele: gal83delta
Strain Background: Sigma1278b
Genotype: MCY4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants are defective in invasive growth in response to limiting glucose. [3] [4]
Allele: gal83 delta
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4567
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
gal83 mutants exhibit wild-type filamentation in response to glucose depletion. [3] [4]
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4581
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of SIP1 suppresses gal83's defect in invasive growth in response to glucose limitation. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY 4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are more defective for invasive growth in response to limiting glucose than gal83 single mutants. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4716
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4708
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg2 partially suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4600
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of SIP1 in a gal83 sip2 double mutant causes an increase in invasion, suggesting Sip1 negatively regulates invasive growth. [3] [4]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: REG1, SIP1, SIP2, MUC1
Phenotype(s): Loss of function (Null)
Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4712
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
Deletion of nrg1 and nrg2 suppresses gal83's defect in invasive growth, plastic adherance, and STA2-lacZ expression, better than deletion of either nrg alone. [3] [4]
Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4597
Together with: NRG2, NRG1, SIP1, SIP2
Phenotype(s): Loss of function (Null)
sip2 gal83 double mutants are defective for filamentation in response to glucose depletion. [3] [4]
Protein Details
Protein Function/Process
One of three alternative beta subunits of the Snf1 kinase complex [5] [6]
References
See Help:References on how to add references
- Jump up ↑ Wiatrowski HA, et al. (2004) Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Mol Cell Biol 24(1):352-61 SGD PMID 14673168
- Jump up ↑ Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60 SGD PMID 12715202
- ↑ Jump up to: 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ Jump up to: 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 4.39 4.40 4.41 4.42 4.43 4.44 4.45 4.46 4.47 submitted by Valmik K. Vyas on 2003-03-27
- ↑ Jump up to: 5.0 5.1 Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 SGD PMID 10990457
- ↑ Jump up to: 6.0 6.1 submitted by Martin C. Schmidt on 2003-02-17
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