YPR189W
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| Systematic name | YPR189W |
| Gene name | SKI3 |
| Aliases | SKI5 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:912664..916962 |
| Primary SGDID | S000006393 |
Description of YPR189W: Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay[1][2][3][4]
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References
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- ↑ Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 SGD PMID 9482746
- ↑ Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 SGD PMID 10744028
- ↑ Lamb JR, et al. (1995) Tetratrico peptide repeat interactions: to TPR or not to TPR? Trends Biochem Sci 20(7):257-9 SGD PMID 7667876
- ↑ Toh-E A, et al. (1978) Chromosomal superkiller mutants of Saccharomyces cerevisiae. J Bacteriol 136(3):1002-7 SGD PMID 363683
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