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Systematic name YPR164W
Gene name MMS1
Aliases RTT108, SLM6
Feature type ORF, Verified
Coordinates Chr XVI:870703..874926
Primary SGDID S000006368

Description of YPR164W: Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay[1][2][3][4][5][6][7]


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  1. Araki Y, et al. (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8(5):465-80 SGD PMID 12694535
  2. Duro E, et al. (2008) Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. DNA Repair (Amst) 7(5):811-8 SGD PMID 18321796
  3. Fujii K, et al. (2009) A role for ubiquitin in the clearance of nonfunctional rRNAs. Genes Dev 23(8):963-74 SGD PMID 19390089
  4. Hryciw T, et al. (2002) MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Mol Genet Genomics 266(5):848-57 SGD PMID 11810260
  5. Scholes DT, et al. (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65 SGD PMID 11779788
  6. Vaisica JA, et al. (2011) Mms1 and Mms22 stabilize the replisome during replication stress. Mol Biol Cell 22(13):2396-408 SGD PMID 21593207
  7. Zaidi IW, et al. (2008) Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. EMBO Rep 9(10):1034-40 SGD PMID 18704118

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