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Systematic name YPL254W
Gene name HFI1
Aliases ADA1, GAN1, SRM12, SUP110
Feature type ORF, Verified
Coordinates Chr XVI:69485..70951
Primary SGDID S000006175

Description of YPL254W: Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions[1][2][3][4][5]


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  1. Bhaumik SR and Green MR (2002) Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo. Mol Cell Biol 22(21):7365-71 SGD PMID 12370284
  2. Grant PA, et al. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11(13):1640-50 SGD PMID 9224714
  3. Horiuchi J, et al. (1997) ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3. Mol Cell Biol 17(6):3220-8 SGD PMID 9154821
  4. Sterner DE and Berger SL (2000) Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64(2):435-59 SGD PMID 10839822
  5. Sterner DE, et al. (1999) Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol 19(1):86-98 SGD PMID 9858534

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