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Systematic name YPL207W
Gene name TYW1
Feature type ORF, Verified
Coordinates Chr XVI:159909..162341
Primary SGDID S000006128

Description of YPL207W: Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron[1][2]


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  1. Li L, et al. (2011) Yap5-regulated transcription of TYW1 protects yeast from high iron toxicity. J Biol Chem () SGD PMID 21917924
  2. Noma A and Suzuki T (2006) Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp Ser (Oxf) (50):65-6 SGD PMID 17150819

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