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Systematic name YPL175W
Gene name SPT14
Aliases CWH6, GPI3
Feature type ORF, Verified
Coordinates Chr XVI:218630..220088
Primary SGDID S000006096

Description of YPL175W: UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins[1][2]


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  1. Kostova Z, et al. (2000) Photoaffinity labelling with P3-(4-azidoanilido)uridine 5'-triphosphate identifies gpi3p as the UDP-GlcNAc-binding subunit of the enzyme that catalyses formation of GlcNAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis. Biochem J 350 Pt 3():815-22 SGD PMID 10970797
  2. Vossen JH, et al. (1995) Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors. Biochim Biophys Acta 1243(3):549-51 SGD PMID 7727533

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