YPL120W

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Systematic name YPL120W
Gene name VPS30
Aliases APG6, ATG6, VPT30
Feature type ORF, Verified
Coordinates Chr XVI:322071..323744
Primary SGDID S000006041


Description of YPL120W: Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1[1][2][3][4]




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References

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  1. Furuya N, et al. (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1(1):46-52 SGD PMID 16874027
  2. Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 SGD PMID 11157979
  3. Seaman MN, et al. (1997) Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol 137(1):79-92 SGD PMID 9105038
  4. Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160

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