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Systematic name YPL086C
Gene name ELP3
Aliases HPA1, KTI8, TOT3
Feature type ORF, Verified
Coordinates Chr XVI:386446..384773
Primary SGDID S000006007

Description of YPL086C: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin[1][2][3][4][5][6]


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  1. Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 SGD PMID 17018299
  2. Frohloff F, et al. (2001) Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin. EMBO J 20(8):1993-2003 SGD PMID 11296232
  3. Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 SGD PMID 12424236
  4. Jablonowski D, et al. (2001) Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Mol Microbiol 42(4):1095-105 SGD PMID 11737649
  5. Winkler GS, et al. (2002) Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A 99(6):3517-22 SGD PMID 11904415
  6. Wittschieben BO, et al. (1999) A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell 4(1):123-8 SGD PMID 10445034

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