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Systematic name YPL085W
Gene name SEC16
Aliases LPF1
Feature type ORF, Verified
Coordinates Chr XVI:387067..393654
Primary SGDID S000006006

Description of YPL085W: COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p[1][2][3][4][5][6]


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  1. Gimeno RE, et al. (1996) COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p. Mol Biol Cell 7(11):1815-23 SGD PMID 8930902
  2. Huijbregts RP, et al. (2000) Lipid metabolism and regulation of membrane trafficking. Traffic 1(3):195-202 SGD PMID 11208102
  3. Ishihara N, et al. (2001) Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell 12(11):3690-702 SGD PMID 11694599
  4. Shaywitz DA, et al. (1997) COPII subunit interactions in the assembly of the vesicle coat. J Biol Chem 272(41):25413-6 SGD PMID 9325247
  5. Supek F, et al. (2002) Sec16p potentiates the action of COPII proteins to bud transport vesicles. J Cell Biol 158(6):1029-38 SGD PMID 12235121
  6. Swigart P, et al. (2000) Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae sec14p are found in the same cell. Biochem J 347 Pt 3():837-43 SGD PMID 10769190

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