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Systematic name YPL049C
Gene name DIG1
Aliases RST1
Feature type ORF, Verified
Coordinates Chr XVI:463839..462481
Primary SGDID S000005970

Description of YPL049C: MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p[1][2][3][4][5]


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  1. Bardwell L, et al. (1998) Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A 95(26):15400-5 SGD PMID 9860980
  2. Cook JG, et al. (1996) Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev 10(22):2831-48 SGD PMID 8918885
  3. Gelli A (2002) Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast. Mol Microbiol 46(3):845-54 SGD PMID 12410840
  4. McCullagh E, et al. (2010) Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol 12(10):954-962 SGD PMID 20852627
  5. Olson KA, et al. (2000) Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Mol Cell Biol 20(12):4199-209 SGD PMID 10825185

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