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Systematic name YPL016W
Gene name SWI1
Aliases ADR6, GAM3, LPA1, [SWI(+)], [SWI+]
Feature type ORF, Verified
Coordinates Chr XVI:521014..524958
Primary SGDID S000005937

Description of YPL016W: Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer[1][2][3][4][5][6]


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  1. Burns LG and Peterson CL (1997) Protein complexes for remodeling chromatin. Biochim Biophys Acta 1350(2):159-68 SGD PMID 9048886
  2. Du Z, et al. (2008) Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Nat Genet 40(4):460-5 SGD PMID 18362884
  3. Mamo A, et al. (2011) An integrated genomic approach identifies ARID1A as a candidate tumor-suppressor gene in breast cancer.LID - 10.1038/onc.2011.386 [doi] Oncogene () SGD PMID 21892209
  4. Peterson CL and Herskowitz I (1992) Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68(3):573-83 SGD PMID 1339306
  5. Peterson CL, et al. (1998) Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family. J Biol Chem 273(37):23641-4 SGD PMID 9726966
  6. Taguchi AK and Young ET (1987) The cloning and mapping of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae. Genetics 116(4):531-40 SGD PMID 3040523

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