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Systematic name YOR359W
Gene name VTS1
Feature type ORF, Verified
Coordinates Chr XV:1011189..1012760
Primary SGDID S000005886

Description of YOR359W: Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain[1][2][3]


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Protein Details

Nucleic Acid Binding

YOR359W binds RNA Specific binding to an RNA stem-loop of CNGGN motif. Involved in CCR4 mediated deadnylation and degradation of targets. [4] [5]



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  1. Dilcher M, et al. (2001) Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6. J Biol Chem 276(37):34537-44 SGD PMID 11445562
  2. Lee CH, et al. (2010) Involvement of Vts1, a structure-specific RNA-binding protein, in Okazaki fragment processing in yeast. Nucleic Acids Res 38(5):1583-95 SGD PMID 20007605
  3. Oberstrass FC, et al. (2006) Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat Struct Mol Biol 13(2):160-7 SGD PMID 16429156
  4. Aviv T, et al. (2003) The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. Nat Struct Biol 10(8):614-21 SGD PMID 12858164
  5. submitted by Tzvi Aviv on 2003-10-10

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