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Systematic name YOR106W
Gene name VAM3
Aliases PTH1
Feature type ORF, Verified
Coordinates Chr XV:519121..519972
Primary SGDID S000005632

Description of YOR106W: Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region[1][2][3][4][5]


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  1. Darsow T, et al. (1997) A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol 138(3):517-29 SGD PMID 9245783
  2. Darsow T, et al. (1998) Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J Cell Biol 142(4):913-22 SGD PMID 9722605
  3. Sato TK, et al. (1998) Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking. Mol Cell Biol 18(9):5308-19 SGD PMID 9710615
  4. Srivastava A and Jones EW (1998) Pth1/Vam3p is the syntaxin homolog at the vacuolar membrane of Saccharomyces cerevisiae required for the delivery of vacuolar hydrolases. Genetics 148(1):85-98 SGD PMID 9475723
  5. Wada Y, et al. (1992) Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem 267(26):18665-70 SGD PMID 1526998

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