YOR028C

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Systematic name YOR028C
Gene name CIN5
Aliases HAL6, YAP4
Feature type ORF, Verified
Coordinates Chr XV:384420..383533
Primary SGDID S000005554


Description of YOR028C: Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions[1][2][3][4]




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References

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  1. Furuchi T, et al. (2001) Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae. Mol Pharmacol 59(3):470-4 SGD PMID 11179441
  2. Hanlon SE, et al. (2011) The Stress Response Factors Yap6, Cin5, Phd1, and Skn7 Direct Targeting of the Conserved Co-Repressor Tup1-Ssn6 in S. cerevisiae. PLoS One 6(4):e19060 SGD PMID 21552514
  3. Mendizabal I, et al. (1998) Yeast putative transcription factors involved in salt tolerance. FEBS Lett 425(2):323-8 SGD PMID 9559673
  4. Sollner S, et al. (2009) Quinone reductase acts as a redox switch of the 20S yeast proteasome. EMBO Rep 10(1):65-70 SGD PMID 19029946

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