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Systematic name YOR011W
Gene name AUS1
Feature type ORF, Verified
Coordinates Chr XV:349679..353863
Primary SGDID S000005537

Description of YOR011W: Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen[1][2][3][4]


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  1. Alimardani P, et al. (2004) SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Biochem J 381(Pt 1):195-202 SGD PMID 15035656
  2. Kohut P, et al. (2011) The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: Dehydroergosterol fluorescence study. Biochem Biophys Res Commun 404(1):233-8 SGD PMID 21110944
  3. Marek M, et al. (2011) The yeast plasma membrane ABC transporter Aus1: Purification, characterization and effect of lipids on its activity. J Biol Chem () SGD PMID 21521689
  4. Wilcox LJ, et al. (2002) Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem 277(36):32466-72 SGD PMID 12077145

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