YOL031C

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Systematic name YOL031C
Gene name SIL1
Aliases SLS1
Feature type ORF, Verified
Coordinates Chr XV:267529..266264
Primary SGDID S000005391


Description of YOL031C: Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein[1][2][3]




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References

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  1. Kabani M, et al. (2000) Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum. Mol Cell Biol 20(18):6923-34 SGD PMID 10958688
  2. Kabani M, et al. (2002) HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor. FEBS Lett 531(2):339-42 SGD PMID 12417338
  3. Tyson JR and Stirling CJ (2000) LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J 19(23):6440-52 SGD PMID 11101517

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