YOL021C

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Systematic name YOL021C
Gene name DIS3
Aliases MTR17, RRP44
Feature type ORF, Verified
Coordinates Chr XV:285426..282421
Primary SGDID S000005381


Description of YOL021C: Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3[1][2][3][4][5][6][7]




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References

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  1. Dziembowski A, et al. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol 14(1):15-22 SGD PMID 17173052
  2. Lebreton A, et al. (2008) Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature 456(7224):993-6 SGD PMID 19060886
  3. Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 SGD PMID 17174896
  4. Lorentzen E, et al. (2008) Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family. Mol Cell 29(6):717-28 SGD PMID 18374646
  5. Schaeffer D, et al. (2009) The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities. Nat Struct Mol Biol 16(1):56-62 SGD PMID 19060898
  6. Schneider C, et al. (2009) The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res 37(4):1127-40 SGD PMID 19129231
  7. Shiomi T, et al. (1998) Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. J Biochem 123(5):883-90 SGD PMID 9562621

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