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Systematic name YOL007C
Gene name CSI2
Feature type ORF, Verified
Coordinates Chr XV:312367..311342
Primary SGDID S000005367

Description of YOL007C: Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene[1][2]


Community Commentary

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Transmembrane Domain GxxxG like motif

The transmembrane domain of Csi2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain contains AGclGA. The presence of a GxxxG like motif [3] strongly indicates that Csi2p dimerises.



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  1. Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 SGD PMID 12140549
  2. Sundin BA, et al. (2004) Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast 21(9):793-800 SGD PMID 15282802
  3. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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