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Systematic name YOL003C
Gene name PFA4
Feature type ORF, Verified
Coordinates Chr XV:322994..321858
Primary SGDID S000005363

Description of YOL003C: Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases[1][2][3][4]


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  1. Lam KK, et al. (2006) Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. J Cell Biol 174(1):19-25 SGD PMID 16818716
  2. Roth AF, et al. (2006) Global analysis of protein palmitoylation in yeast. Cell 125(5):1003-13 SGD PMID 16751107
  3. Smotrys JE, et al. (2005) The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 170(7):1091-9 SGD PMID 16186255
  4. Valdez-Taubas J and Pelham H (2005) Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J 24(14):2524-32 SGD PMID 15973437

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