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Systematic name YNL330C
Gene name RPD3
Aliases MOF6, REC3, SDI2, SDS6
Feature type ORF, Verified
Coordinates Chr XIV:19302..18001
Primary SGDID S000005274

Description of YNL330C: Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members[1][2][3][4][5][6][7]


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  1. Carrozza MJ, et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92 SGD PMID 16286007
  2. Knott SR, et al. (2009) Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev 23(9):1077-90 SGD PMID 19417103
  3. Kremer SB and Gross DS (2009) SAGA and Rpd3 Chromatin Modification Complexes Dynamically Regulate Heat Shock Gene Structure and Expression. J Biol Chem 284(47):32914-31 SGD PMID 19759026
  4. Nyswaner KM, et al. (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214 SGD PMID 18202368
  5. Ruiz-Roig C, et al. (2010) The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol Microbiol 76(4):1049-62 SGD PMID 20398213
  6. Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 SGD PMID 8962081
  7. Zhou J, et al. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res 37(11):3699-713 SGD PMID 19372273

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