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Systematic name YNL258C
Gene name DSL1
Aliases RNS1
Feature type ORF, Verified
Coordinates Chr XIV:160373..158109
Primary SGDID S000005202

Description of YNL258C: Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene[1][2][3][4][5]


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  1. Andag U, et al. (2001) The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast. J Biol Chem 276(42):39150-60 SGD PMID 11493604
  2. Ishikawa T, et al. (2005) Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. J Gen Appl Microbiol 51(1):73-82 SGD PMID 15942868
  3. Reilly BA, et al. (2001) Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Mol Biol Cell 12(12):3783-96 SGD PMID 11739780
  4. Tripathi A, et al. (2009) Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol 16(2):114-23 SGD PMID 19151722
  5. Wainman A, et al. (2012) The Drosophila RZZ complex: roles in membrane traffic and cytokinesis. J Cell Sci () SGD PMID 22685323

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