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Systematic name YNL216W
Gene name RAP1
Aliases GRF1, TBA1, TUF1
Feature type ORF, Verified
Coordinates Chr XIV:241689..244172
Primary SGDID S000005160

Description of YNL216W: Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)[1][2][3][4][5]


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  1. Chen Y, et al. (2011) A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol 18(2):213-21 SGD PMID 21217703
  2. Konig P, et al. (1996) The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell 85(1):125-36 SGD PMID 8620531
  3. Lieb JD, et al. (2001) Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet 28(4):327-34 SGD PMID 11455386
  4. Pina B, et al. (2003) The different (sur)faces of Rap1p. Mol Genet Genomics 268(6):791-8 SGD PMID 12655405
  5. Zhang W, et al. (2011) Solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae reveals a novel fold. Biochem Biophys Res Commun 404(4):1055-9 SGD PMID 21187076

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