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Systematic name YNL049C
Gene name SFB2
Aliases ISS1
Feature type ORF, Verified
Coordinates Chr XIV:537911..535281
Primary SGDID S000004994

Description of YNL049C: Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p[1][2][3]


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  1. Kurihara T, et al. (2000) Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Biol Cell 11(3):983-98 SGD PMID 10712514
  2. Miller EA, et al. (2003) Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114(4):497-509 SGD PMID 12941277
  3. Peng R, et al. (2000) Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members. J Biol Chem 275(15):11521-8 SGD PMID 10753972

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