YMR313C

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Systematic name YMR313C
Gene name TGL3
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:901307..899379
Primary SGDID S000004930


Description of YMR313C: Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation[1][2][3]




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Community Commentary

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Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Together with: TGL4
Phenotype(s): Loss of function (Null), Recessive, Viable

tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [4] [5]





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References

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  1. Athenstaedt K and Daum G (2003) YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J Biol Chem 278(26):23317-23 SGD PMID 12682047
  2. Kurat CF, et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33(1):53-63 SGD PMID 19150427
  3. Rajakumari S and Daum G (2010) Janus-faced Enzymes Yeast Tgl3p and Tgl5p Catalyze Lipase and Acyltransferase Reactions. Mol Biol Cell 21(4):501-10 SGD PMID 20016004
  4. Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 SGD PMID 16267052
  5. submitted by Sepp D. Kohlwein on 2006-05-22

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