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Systematic name YMR284W
Gene name YKU70
Aliases HDF1, KU70, NES24
Feature type ORF, Verified
Coordinates Chr XIII:838187..839995
Primary SGDID S000004897

Description of YMR284W: Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair[1][2][3][4][5][6][7][8]


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  1. Bertuch AA and Lundblad V (2003) The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol 23(22):8202-15 SGD PMID 14585978
  2. Boulton SJ and Jackson SP (1996) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J 15(18):5093-103 SGD PMID 8890183
  3. Boulton SJ and Jackson SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 17(6):1819-28 SGD PMID 9501103
  4. Laroche T, et al. (1998) Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr Biol 8(11):653-6 SGD PMID 9635192
  5. Mages GJ, et al. (1996) Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination. J Biol Chem 271(14):7910-5 SGD PMID 8626469
  6. Martin SG, et al. (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97(5):621-33 SGD PMID 10367891
  7. Milne GT, et al. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4189-98 SGD PMID 8754818
  8. Porter SE, et al. (1996) The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res 24(4):582-5 SGD PMID 8604297

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