YMR138W

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Systematic name YMR138W
Gene name CIN4
Aliases GTP1, UGX1
Feature type ORF, Verified
Coordinates Chr XIII:545155..545730
Primary SGDID S000004746


Description of YMR138W: GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog[1][2][3][4]




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References

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  1. Bhamidipati A, et al. (2000) ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. J Cell Biol 149(5):1087-96 SGD PMID 10831612
  2. Hoyt MA, et al. (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34 SGD PMID 2403635
  3. Stearns T, et al. (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62 SGD PMID 2407611
  4. Veltel S, et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol 15(4):373-80 SGD PMID 18376416

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