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Systematic name YMR137C
Gene name PSO2
Aliases SNM1
Feature type ORF, Verified
Coordinates Chr XIII:544963..542978
Primary SGDID S000004745

Description of YMR137C: Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation[1][2][3][4][5][6]


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  1. Angulo JF, et al. (1986) Induction of polypeptides in Saccharomyces cerevisiae after ultraviolet irradiation. Biochem Biophys Res Commun 138(2):679-86 SGD PMID 3527168
  2. Brendel M, et al. (2003) Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae. Mutat Res 544(2-3):179-93 SGD PMID 14644320
  3. Cassier C and Moustacchi E (1981) Mutagenesis induced by mono- and bi-functional alkylating agents in yeast mutants sensitive to photo-addition of furocoumarins (pso). Mutat Res 84(1):37-47 SGD PMID 7035927
  4. Li X and Moses RE (2003) The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiae. DNA Repair (Amst) 2(1):121-9 SGD PMID 12509272
  5. Magana-Schwencke N, et al. (1982) The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains. Proc Natl Acad Sci U S A 79(6):1722-6 SGD PMID 6281782
  6. Wilborn F and Brendel M (1989) Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum (II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity. Curr Genet 16(5-6):331-8 SGD PMID 2692851

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