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Systematic name YMR125W
Gene name STO1
Aliases CBC1, CBP80, GCR3, SUT1
Feature type ORF, Verified
Coordinates Chr XIII:517539..520446
Primary SGDID S000004732

Description of YMR125W: Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80[1][2][3][4][5][6]


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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Das B, et al. (2000) The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol 20(8):2827-38 SGD PMID 10733586
  3. Das B, et al. (2003) Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae. Mol Cell Biol 23(16):5502-15 SGD PMID 12897126
  4. Fortes P, et al. (1999) Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol 19(10):6543-53 SGD PMID 10490594
  5. Gao Q, et al. (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A 102(12):4258-63 SGD PMID 15753296
  6. Lewis JD, et al. (1996) A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res 24(17):3332-6 SGD PMID 8811086

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