YMR086W

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Systematic name YMR086W
Gene name SEG1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:439208..442090
Primary SGDID S000004692


Description of YMR086W: Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes[1][2][3][4][5][6][7]




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References

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  1. Deng C, et al. (2009) Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells. Mol Cell Proteomics 8(6):1413-23 SGD PMID 19269952
  2. Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403
  3. Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 SGD PMID 12140549
  4. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  5. Moreira KE, et al. (2012) Seg1 controls eisosome assembly and shape. J Cell Biol 198(3):405-20 SGD PMID 22869600
  6. Seger S, et al. (2011) Formation and stability of eisosomes in the filamentous fungus Ashbya gossypii. J Cell Sci 124(Pt 10):1629-34 SGD PMID 21525038
  7. Tadi D, et al. (1999) Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae. Yeast 15(16):1733-45 SGD PMID 10590462

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