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Systematic name YLR409C
Gene name UTP21
Feature type ORF, Verified
Coordinates Chr XII:937233..934414
Primary SGDID S000004401

Description of YLR409C: Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma[1][2][3][4][5]


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  1. Bernstein KA, et al. (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell 3(6):1619-26 SGD PMID 15590835
  2. Flom G, et al. (2005) Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae. Curr Genet 47(6):368-80 SGD PMID 15871019
  3. Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 SGD PMID 12150911
  4. Perez-Fernandez J, et al. (2007) The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol 27(15):5414-29 SGD PMID 17515605
  5. Skarie JM and Link BA (2008) The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. Hum Mol Genet 17(16):2474-85 SGD PMID 18469340

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