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Systematic name YLR398C
Gene name SKI2
Feature type ORF, Verified
Coordinates Chr XII:919019..915156
Primary SGDID S000004390

Description of YLR398C: Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay[1][2][3][4]


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  1. Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 SGD PMID 9482746
  2. Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 SGD PMID 10744028
  3. Toh-E A, et al. (1978) Chromosomal superkiller mutants of Saccharomyces cerevisiae. J Bacteriol 136(3):1002-7 SGD PMID 363683
  4. Widner WR and Wickner RB (1993) Evidence that the SKI antiviral system of Saccharomyces cerevisiae acts by blocking expression of viral mRNA. Mol Cell Biol 13(7):4331-41 SGD PMID 8321235

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